HYPOLIPIDEMIC EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA LEAVES ON DYSLIPIDEMIA FOLLOWING HEPATIC INJURY INDUCED BY CARBON TETRACHLORIDE IN ALBINO RATSAbstract
Background: The Mimosa pudica, is well known across the world for its different pharmacological activities such as anti diabetic, antitoxin,antioxidant and wound healing activities.In the present study we investigated the hypolipidemic effects of ethanolic extract of leaves of Mimosa pudica linn against dyslipidemia following carbon tetrachloride (CCl4) induced hepatic injury in albino rats. Methods: Liver damage was induced in rats by treating them with CCl4 (1ml/kg /bw), administered subcutaneously, on alternate days for one week. Several biochemical parameters like triglyceride (TG),total cholesterol (TC), very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) were taken into consideration to assess dyslipidemic changes .The effects of ethanolic extract of Mimosa pudica (at a dose of 400mg/kg) was observed on the following parameters. In addition to biochemical parameters liver weight and histological sections were also studied. The statistical analysis of data was done by using one way ANOVA followed by Dunnet’s t test. Results: Administration of ethanolic extract of Mimosa pudica significantly prevented carbon tetrachloride induced elevation of serum TG, TC, VLDL and LDL levels. Histological examination of the liver section revealed improved hepatic architecture, after administration of Mimosa pudica. Conclusions: Our study demonstrates hypolipidemic effect of Mimosa pudica in dyslipidemia following carbon tetrachloride induced liver injury.
Ayan Purkayastha *, Pinaki Chakravarty and Babul Dewan
Department of Pharmacology, Silchar Medical College and Hospital, Silchar, Assam, India
04 March, 2016
08 April, 2016
31 May, 2016
01 August 2016