IDENTIFICATION OF ANTI HYPERLIPIDEMIC ACTIVITY OF CERIUM OXIDE NANO PARTICLES IN RAT MODELAbstract
Cerium oxide is an oxide of the rare earth metal which is widely used for several disorders. However, there are no complete toxicity studies done on it. The purpose of present study is to evaluate acute and Anti-hyper lipidemic activity of cerium oxide nano particles on Wistar albino rats. In this study, Cerium oxide was administered to six rats in different groups in different concentrations (100mg/kg and 200mg/kg) observed for 14 days. After the course, blood was collected and it was calculated for biochemical parameters like serum triglycerides, serum cholesterol, Very low density lipoprotein cholesterol (VLDL), Serum HDL cholesterol, Serum LDL cholesterol levels in the test and standard group of animals which were compared with ccl4 induced group of animals. The results showed that the mechanism of action of anti-hyper lipidemic activity of Cerium oxide nano particles on dose dependent manner.
R. Narasimha Naik *, S. Tirupati Rao , D. Durga Rao , K. Ramalingeswara Rao and T. Mohan Rao
Department of Pharmacology, Vagdevi College of Pharmacy, Gurazala - 522415, Andhra Pradesh, India.
27 June, 2014
28 August, 2014
29 October, 2014
01 February, 2015