IDENTIFICATION, QUANTITATIVE DETERMINATION AND ANTIDEPRESSANT ACTIVITY OF CHLOROGENIC ACID AND GALLIC ACID FROM MORUS ALBA LEAVESAbstract
Objective: The present study is considered to estimate preliminary phytochemical components, physicochemical parameters, HPTLC chromatographic studies and antidepressant activity of chlorogenic acid & gallic acid present in extracts of Morus alba leaves. Methods: Total phenol content, total flavonoid content, total tannin content, HPTLC fingerprinting analysis for compounds like chlorogenic acid & gallic acid responsible for antioxidant activity and antidepressant activity by TST & FST. Result: Preliminary phytochemical studies shows the presence of good phenol (21.75 ± 1.21) and flavonoid (14.83 ± 2.34) content. HPTLC fingerprinting by comparing extract values with standards available of chlorogenic acid and gallic acid also shows the presence of these components in the methanolic and ethanolic extracts of Morus alba leaves, which were further used to screen antidepressant activity and shows substantial antidepressant activity in the plant. Conclusion: Our results recommend that Morus alba leaves are may be demonstrated to be an acceptable natural antioxidant and antidepressant with various bioactive components used for the treatment of numerous other ailments.