IMMUNOMODULATORY POTENTIAL OF A POLYHERBAL PREPARATION FOLLOWING ACTIVATION OF MURINE MACROPHAGESAbstract
Five medicinal plants used in the traditional medicine of India, were selected for studying their immunomodulatory potential through the activation of macrophages, individually and in synergism. The plants were Boswellia serrata Roxb., Curcuma longa L., Glycyrrhiza glabra L., Tribulusterrestris L., and Tylophora indica (Burm f.) Merr. In the present study, strong stimulation of antigen specific and nonspecific immunity was evidenced by increase in phagocytic index, percentage inhibition of yeast digestion, macrophage activation and intracellular killing capacity of all the extracts individually and of their combination in murine model. All were found to increase in a dose dependent manner. The results provide scientific basis for widespread use of these plants and their combination as tonic for immunostimulation and chronic ailments.
Kavita Chahal *, NitinNema and N. P. Shukla
Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal, Madhya Pradesh, India
14 January, 2015
19 April, 2015
05 May, 2015
01 August, 2015