IMPACT OF ALCOHOL ON RAT HEART AND AORTIC TISSUE ACETYLCHOLINE CONTENT LEVELS IN VITRO AND IN VIVOAbstract
Acetylcholine satisfies all criteria for a transmitter substance. Its most widely recognized action sites are the endings of vertebrate motor nerves, the endings of the automatic pre ganglionics and the parasympathetic post ganglionics. It appears also to be the transmitter of motor nerves in all advanced invertebrate animals except the arthropods where it seems to separate at the endings of sensory nerves. Acetylcholine is concerned with various visceral functions in both invertebrates and vertebrates. The impact of 20% ethanol (w/v) at selected doses of 5gm/kg wt over 5 and10 weeks in vivo and 100-1000 µl in vitro on the heart and aortic tissue acetylcholine content activity was reported. Alcohol is selected doses appeared to inhibit the rat and aortic tissue based Ach levels both in vitro and in vivo.
M. Yugandhar*, M. Rajeswara Rao
Department of Zoology, S.V. University, Tirupati – 517502, Andhra Pradesh, India
10 October, 2013
29 November, 2013
10 February, 2014