IMPACT OF GENETICS IN NEURODEVELOPMENTAL DISORDERS

A category of illnesses known as neurodevelopmental disorders is predominantly linked to neurodevelopmental dysfunctions. The two most prevalent neurodevelopmental disorders, “Attention Deficit/Hyperactivity Disorders (ADHD)” as well as“Autism Spectrum Disorders (ASD)”, affect both humans and lower-class species like rats, mice and zebra fish. The purpose of this review is to identify the behavioral changes brought on by certain Neurodevelopmental disorders-Risk genes, such as CHD8, SHANK3, LPHN3, SLC6A3, etc., and to summarize their genetic screening and epidemiological researches, which directed various neurodevelopmental disorders in various organisms brought on by the interaction of genetic and environmental factors, as well as their genetic screening, which can be used to identify those diseases in humans by this orthologous gene that are present in humans. The majority of genes linked to neurodevelopment disorders were shown to have an excess of de novo mutations (DNMs), but case-control mutation burden research has not been able to prove their importance. We could identify the behavioral anomalies caused by these genes in different species for the development of neuropsychotic disorders by integrating the published scientific data. We have indeed been able to include the several genetic tests available to diagnose the diseases, as well as the various newly discovered genes that cause ADHD and ASD.