IMPLICATION OF NANOPARTICLES FOR CONTROLLED DRUG DELIVERY SYSTEMAbstract
Pharmaceutical nanoparticles are submicron-sized, colloidal vehicles that carry drugs to the target or release drugs in a controlled way in the body. Controlled drug delivery offers advantages like reduced dosing frequency, better therapeutic control, reduced side effects, and, consequently, better patient compliance. Biodegradable polymers are utilized to prepare Nanoparticles which offers advantages like versatile degradation kinetics, non-toxicity, and biocompatibility. Nanoparticles can be prepared by various techniques & are evaluated for parameters like: Particle size, Morphological properties, Thermal properties, surface chemistry & drug release etc. Nanoparticles can be converted into dry form & formulated in various dosage forms depending on the route of application. Several marketed formulation based on controlled drug delivery are also available which is the fruitful result of the development of biodegradable polymer, newer techniques for preparation, scale up procedure & better control over all the required manufacturing processes.
Dipti Desai* and Dushyant Shah
Department of Pharmacy, Pioneer Pharmacy Degree College , Syajipura, Nr. Aajwa cross road, Vadodara, Gujarat, India
07 March, 2013
08 May, 2013
17 June, 2013
01 July, 2013