IMPROVEMENT IN BIOAVAILABILITY OF POORLY SOLUBLE DRUG BY SELF MICRO EMULSIFYING DRUG DELIVERYAbstract
Solubility is the rate-limiting step for bioavailability of poorly water-soluble drugs. The solubility of poorly water-soluble drugs can be enhanced by incorporating active pharmaceutical ingredients into oral lipid-based drug delivery systems. Self micro emulsifying drug delivery system (SMEDDS) is a researcher’s choice amongst other oral lipid drug delivery systems because it offers advantages like simplicity to manufacture, convenience in scale-up, less interference of food on the dosage form and has the capability to deliver peptides. SMEDDS acts as a drug delivery carrier in which a broad range of different drug moieties can be incorporated. The bioavailability of lipophilic drugs can be significantly increased by formulating in the SMEDDS form. The present review provides a comprehensive summary for types of SMEDDS, manufacturing process, formulations aspects, evaluation characteristics, and patents registered on account of oral lipid drug delivery system.
A. Shelar, J. Mahore *, S. Deshkar and R. Trivedi
Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.
26 October 2019
29 February 2020
19 April 2020
01 August 2020