IMPROVEMENT OF SOLUBILITY AND DISSOLUTION RATE OF CANDESARTAN CILEXETIL BY SOLID DISPERSION IN POLYVINYL PYRROLIDONEAbstract
The aim of the present study was to characterize solid dispersion (SD) of Candesartan cilexetil (CC) prepared with polyvinyl pyrrolidone K30 (PVP) for enhancing its solubility and bioavailability. The SDs of Candesartan was prepared by solvent evaporation method. The prepared SDs were evaluated for saturation solubility, practical yield, drug content, and in vitro dissolution study, IR-Spectroscopy, X-ray powder diffractometry (XRD) and differential scanning calorimetry (DSC). The dissolution rates of SDs prepared with PVP was much faster than the pure CC and physical mixtures (PM). The data from the XRD showed that drug was crystalline in bulk and in PM. Significant change in melting peak in DSC thermograms of SDs revealed amorphization. SDs showed marked increase in the solubility of CC with increasing carrier concentration. At the highest ratio of carriers the drug solubility was enhanced about 6-folds for SD in PVP. The dissolution rate was increased with increasing carrier concentration at pH 6.5. XRD data revealed a remarkable interaction between the CC and the carrier that enhanced drug dissolution. The 1:4 ratios were sufficient for conversion of Candesartan to amorphous form.
Vishal S. Katti, Atul M. Kadam*, Sandip M. Honmane, Shitalkumar Patil, Sachin Patil and Kiran Bhamare
Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth-Vadgaon, Kolhapur– 416112, Maharashtra, India
09 November, 2013
26 December, 2013
23 March, 2014
01 April, 2014