IMPROVEMENT OF SOLUBILITY OF BADLY WATER SOLUBLE DRUG (IBUPROFEN) BY USING SURFACTANTS AND CARRIERSAbstract
Although there was a great interest in solid dispersion systems during the past four decades to increase dissolution rate and bioavailability of badly water-soluble drugs, their profitable use has been very limited, primarily because of manufacturing difficulties and stability problems. In this study solid solutions of drugs were generally produced by fusion method. The drug along with the excipients (surfactants and carriers) was heated first and then hardened by cooling to room temperatures. They were then pulverized, sieved, and encapsulated into hard gelatin capsules, then drug release was studied USP basket method at 50 rpm and controlling the temperature 370C. Ibuprofen is a non-steroidal anti-inflammatory drug commonly used to reduce fever, pain and stiffness. An attempt was taken to study the effect of surfactants and carriers in badly water soluble drug (Ibuprofen) by using solid solution method. In this trial Sodium Lauryl Sulfate, Poloxamer, Polyethylene Glycol (PEG)-6000, Tween 80 and Polyvinylpyrrolidone (PVP) K30 were used as solubilising agent. Ibuprofen is badly water soluble drug and distilled water was used as dissolution medium. The amount of drug was measured form the absorbance of UV spectrophotometer at 214nm. The release of drug was schemed in a choice of release pattern. The present study shows that PEG 6000, Sodium Lauryl Sulfate, Poloxamer, Tween 80 and PVP K30 enhanced the release profile of capsule ibuprofen. From this effort it is possible to increase the release of ibuprofen by using surfactants and carriers.
Md. Zakaria Faruki*, Rishikesh, Elizabeth Razzaque, Mohiuddin Ahmed Bhuiyan
Department of Pharmacy, University of Asia Pacific, Dhaka-1209, Bangladesh
10 December, 2012
23 January, 2013
18 March, 2013
01 April, 2013