IN-SILICO ANALYSIS OF MTA1 AS DRUG TARGET AGAINST NATURAL ANTIOXIDANTSAbstract
The protein MTA1 with histone deacetylase activity is a member of the nucleosome remodeling complex encoded by the mta1 gene is frequently overexpressed in biologically aggressive epithelial neoplasms. MTA1 is a nuclear co-regulatory molecule that is highly expressed in many cancers and correlates with tumor metastasis and progression. MTA1 alters signaling events in the tumor micro-environment. MTA1 contributes to cancer progression, may serve as a biomarker and therapeutic target for cancer. The main objective of this study is to perform in–silico docking studies and energy minimizations for active sites of mutated MTA1 protein by selecting different naturally available antioxidant molecules in foods to facilitate ligand-binding site interactions and identify the best from the selected ligands.
R. Pinnamaneni *, P. Gandham, J. Tatineni, R. Vemparala, S. Shaik and S. Kamma
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Greenfields, Vaddeswaram, Guntur, Andhra Pradesh, India.
02 March 2020
02 June 2020
18 February 2021
01 March 2021