IN-VITRO AND IN-VIVO EVALUATION OF ANTIASTHMATIC ACTIVITY OF PICRORHIZA KURROA PLANTAbstract
Asthma isa disease of the human respiratory system. The ethanolic extract of the roots of Picrorhiza kurroa was evaluated for antiasthmatic activity by using in-vivo and in-vitro model in guinea pigs. Animal studies used the histamine induced broncho-constriction in guinea pigs. The extract showed a maximum degree of protection of 52.16 % which was comparable to that of salbutamol 65.83 %. The effect of the ethanolic extract of the plant on isolated guinea pig ileum was studies to know the mechanism by which the extract exhibited muscle relaxant activity. The study showed the extract is effective against histamine and acetylcholine induced contraction. The extract exhibited relaxation effect against histamine and acetylcholine induced contraction at a concentration of 100 mg/ml. The result revealed that the ethanolic extract produced antiasthmatic activity due to presence of saponins and flavonoids.
R. Sehgal*, A. Chauhan , U.K.Gilhotra and Aindry Gilhotra
Department of Chemistry, S. K. College, Sikar, Rajasthan, India
16 April, 2013
08 June, 2013
15 August, 2013
01 September, 2013