IN-VITRO ANTIBACTERIAL AND CYTOTOXICITY EVALUATION OF SOME NOVEL TETRAZOLE DERIVATIVESAbstract
A series of tetrazol derivatives 1(a-c) and 2(a-c) were synthesized by Mannich base reaction. Synthesized compounds 1(a-c) and 2(a-c) were confirmed by IR, ¹H NMR, ¹³C NMR, mass spectral, and elemental analysis. Synthesized compounds 1(a-c) and 2(a-c) were screened for dental plaque bacteria and cytotoxicity activity. The compound 1b was highly active against Enterococcus feacalis in antibacterial screening. The synthesized compounds have been screened for preliminary cytotoxicity against HepG2 (Liver), Hela (Cervical) and MCF-7 (Breast) cancer cells. The compound (1c) is highly active against MCF-7(Breast), and compound (2b) is highly active against HepG2 (Liver). Therefore, current study demonstrates the antibacterial and cytotoxicity activity potential of new tetrazole derivatives and provides future insights for developing dental plaque antibacterial drugs.
A. Ahamed, I. A. Arif, M. Moydeen, R. S. Kumar and A. Idhayadhulla *
Department of Chemistry, Nehru Memorial College, Puthanampatti, Tiruchirappalli , Tamil Nadu, India.
19 November, 2017
16 February, 2018
19 February, 2018
01 August, 2018