IN-VITRO ANTICANCER ACTIVITY OF CASSIA FISTULA FRUIT AND LEAF EXTRACT ON LIVER CANCER CELL LINEAbstract
Among different neoplastic lesions, hepatocellular carcinoma plays a pivotal role due to the extreme difficulty of treating it in advanced conditions. Research shows that there is a high intractability towards chemotherapy for this disease. Therefore, using medicinal plants can be another approach to fend off this grim scenario and pave a new way to prolong survival time. For this purpose, the ethanolic extracts of leaves and fruits of Cassia fistula (Golden shower) as a probable anticancer drug have been administered in the liver cancer cell line, HEPG2 and the gene expression of cytokines (interleukin-6, interleukin-8, interleukin IL-1β, transforming growth factor-TGF-β1, tumour necrosis factor-TNF-α) against this treatment has been analyzed in the present work. The current study revealed a significant reduction in the expression of pro-inflammatory cytokines by the application of these extracts demonstrating their vital role in suppressing tumour growth and proliferation in liver cancer. It appears that important phytochemicals played a key role in decreasing the expression of these cytokines. The combination of leaves and fruit extracts of Cassia fistula can be a promising agent to treat these patients.
Phalguni Chowdhury, Debasmita Chatterjee, Banhishikha Singh, Krishnendu Paira and Satadal Das *
R&D Unit under Department of Biotechnology, Heritage Institute of Technology, Chowbaga, West Bengal, India.
04 January 2023
26 March 2023
25 April 2023
01 September 2023