IN-VITRO ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF THE COMBINED S-ALLYL CYSTEINE AND TAURINEAbstract
Diabetes mellitus is one of the familiar metabolic disorders affecting the global population. In the modern system of medicine, there are still no satisfactory promising agents available for the effective management and treatment of diabetes. The current study aimed to investigate the in-vitro antioxidant and antidiabetic potential of the combination of s-allyl cysteine (a phytochemical) and taurine (an endogenous biomolecule). Despite numerous pharmacotherapeutic properties of s-allyl cysteine (SAC) and taurine (TAU), their combined in-vitro effects as antidiabetic and antioxidant had not been explored, and scientific data were also lacking to be exposed as yet. The combination (SAC/TAU) gives in-vitro antioxidant activity when subjected to the tests like reducing power, hydrogen peroxide & DPPH radical scavenging assays and in-vitro antidiabetic activity when subjected to the tests like α-glucosidase & α-amylase inhibitory activities. The IC50 value were reducing power test (significant with the ascorbic acid), hydrogen peroxide radical scavenging test (4.84 µg/ml), DPPH assay (16.30 µg/ml), α-amylase inhibitory activity test (17.26 µg/ml), and α-glucosidase inhibitory activity test (5.73 µg/ml). Hence, the in-vitro antioxidant and antidiabetic results indicate the potential of the combination (SAC/TAU) to manage hyperglycemia and related complications.
Nadeem Rais *, Akash Ved, Rizwan Ahmad, Kehkashan Parveen and Mohd. Mujeeb
Department of Pharmacy, Bhagwant University, Ajmer, Rajasthan, India.
02 December 2020
21 May 2021
25 May 2021
01 November 2021