IN-VITRO ANTIUROLITHIATIC POTENTIAL OF LEAVES OF EUPHORBIA HIRTA L. AGAINST CALCIUM OXALATE KIDNEY STONESAbstract
Plant Euphorbia hirta L. is a common weed plant that belongs to the family Euphorbiaceae characterized by the presence of milky latex in leaves and stems. Phytochemical screening of leaves of Euphorbia hirta L. confirmed the presence of alkaloids, cardiac glycosides, flavonoids, phenolic compounds, tannin and terpenoids. FT-IR confirms the formation of calcium oxalate crystals with major peaks at 3331.07, 1608.63, 1317.38, and 775.38, which corresponds to asymmetric O-H bending, C=O stretching, C-O stretching and C-H bending. Nucleation and aggregation assay has been done to investigate the in-vitro antiurolithiatic potential of leaves of Euphorbia hirta L., and significant % inhibition has been observed for nucleation and aggregation of calcium oxalate kidney stones. Maximum % inhibition has been observed at 1000 µg/ml concentration with 55.81% and 73.17% inhibition, respectively. % inhibition of nucleation and aggregation increases with the increasing concentration of plant E. hirta. GC- MS confirmed the presence of different active compounds.
D. Kain, S. Kumar *, A. Suryavanshi and A. Arya
Medicinal Plant Research Laboratory, Department of Botany, Ramjas College, University of Delhi, Delhi, India.
06 February 2020
26 June 2020
30 June 2020
01 February 2021