IN VITRO CHARACTERIZATION OF NATURAL MUCOADHESIVE AGENT ISOLATED FROM OCIMUM AMERICANUM SEEDAbstract
Aim of present investigation was to isolate natural mucoadhesive agent from Ocimum americanum seeds and characterize through in vitro mucoadhesion methods, FTIR and DSC studies. Mucoadhesion force of isolated natural mucoadhesive agents and synthetic polymer Carbopol 934P was determined using in vitro mucoadhesion methods viz. Wihelmy’s method, falling sphere method and modified physical balance method. The research study reveals that the natural mucoadhesive agent isolated from Ocimum americanum seed was shown promising mucoadhesion strength. The formation of hydrogen bond by natural mucoadhesive agent with mucosa was confirmed by FTIR spectra showing carboxyl and hydroxyl groups. Natural mucoadhesive agent may be useful to formulate mucoadhesive drug delivery systems as it bears excellent mucoadhesion property and advantageous over synthetic polymers for less toxicity, biocompatibility, biodegradability and cost.
P. Perumal, Avinash B. Gangurde* and Prashant S. Malpure
JKK Nataraja College of Pharmacy, Komarapalayam-638 183, Tamil Nadu, India
07 June, 2012
16 July, 2012
27 August, 2012
01 September, 2012