IN-VITRO CYTOTOXIC ACTIVITY OF LEAF EXTRACTS OF IPOMOEA JACQ. SPECIES AGAINST A 549AND HEP-G2CELL LINESAbstract
Members of the genus Ipomoea of family Convolvulaceae besides being some of the most beautiful ornamental plants cultivated for their bell shaped flowers, are also of medicinal value, with some of them reported as cytotoxic agents against some cancer cell lines. The present study evaluates the anticancer activity of the leaf extracts of ten Ipomoea Jacq. Species growing in and around Mumbai, India, on the A 549 cellline and Hep-G2 cell line evaluated by the SRB assay. The crude aqueous extracts of leaves of Ipomoea species studied had significant cytotoxic effect on HEP G2 Cell Line and showed significant inhibitory effect on A549 cell line. , I. Cairica was the best growth inhibitor (GI50at 30.6µg/ml) for HEP G2 cell line followed by I. Hederifolia (GI50 at 38.1 µg/ml), I. Carnea (GI50 at 40.0 µg/ml). Considering the A549 cell line, none of the crude extracts showed GI50 inhibition upto80 µg/ml with the exception of I. aquatic which showed GI50at 75.6 µg/ml
Vinaya A. Rane* and Behnaz B. Patel
Department of Botany, R. Ruia College, Matunga, Mumbai - 400 019, M.H., India.
12 May, 2014
07 August, 2014
16 September, 2014
01 January, 2015