IN-VITRO DRUG RELEASE KINETICS FROM CONTROLLED-RELEASE GLIPIZIDE MATRIX TABLETS AND THE INFLUENCE OF TWO DIFFERENT DILUENTS ON DRUG RELEASE PATTERNSAbstract
The objective of the study was to formulate and evaluate controlled release glipizide matrix tablets for the release rate, release patterns, and the mechanism involved in the release process of the drug. Formulations with hydrophobic and hydrophilic polymer in several drug-to-polymer ratios and using water-soluble and water-insoluble diluents were compressed into tablets using the direct compression method. By using an eight-station dissolution rate test apparatus, the drug release study was analyzed in phosphate buffer of pH 7.4. For the determination of the release mechanism and drug release kinetics, various mathematical/kinetic models were employed. Release was relatively faster with water-soluble diluent lactose when compared to water-insoluble diluent dicalcium phosphate (DCP) at all concentrations of Starch Acetate (SA) and Ethylene Vinyl Acetate copolymer (EVA). The difference factor f1 and similarity factor f2 between prepared formulation TSAF2 and the marketed formulation was found to be similar. Therefore matrix tablets prepared to employ starch acetate (TSAF2) are considered suitable for controlled release of Glipizide over 24 h (i.e. once-a-day administration).
Palanichamy Seenivasan *, K. P. R. Chowdary and J. Sathyanarayana Murthy
Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education & Research, Porur, Chennai, Tamil Nadu, India.
22 November 2020
20 March 2021
25 May 2021
01 November 2021