IN VITRO EVALUATION FOR CYTOTOXIC ACTIVITY OF THREE FERULA SPECIES
AbstractTo study the effect of herbal materials as anti-cancer agents, the first step is to evaluate their cytotoxic activity; thus in the present study, the cytotoxic activity of the extracts and fractions of Ferula szowitsiana, F. hirtella and F. oopoda in MCF-7, HT-29, A-549 and HepG-2 cells have been investigated through MTT assay. The result showed that the n-hexane and chloroform fractions of F. szowitsiana and F. hirtella were the most cytotoxic to all cell lines while F. hirtella extracts/fractions demonstrated little or no cytotoxic activity. The results suggest that the non-polar/semi polar constituents might be the cause for the cytotoxic behavior of the species.
Article Information
28
2673-2676
372KB
1043
English
IJPSR
M. Hamzeloomoghadam , S. Esmaeili , F. Fotoohi , F. Naghibi , A. Pirani , H. Hajimehdipoor*
Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences 2, Tehran, Iran
hajimehd@tums.ac.ir
04 March, 2013
20 May, 2013
20 May, 2013
10.13040/IJPSR.0975-8232.4(7).2673-76
01 July, 2013
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