IN VITRO EVALUATION OF ANTIOXIDANT ACTIVITY OF DILLENIA INDICA LINN. LEAF EXTRACTAbstract
Reactive oxygen species (ROS) are thought to underline the process of ageing and the pathogenicity of various diseases, such as neurodegenerative disorders and cancer. The use of traditional medicine is widespread and plants still present a large source of natural antioxidants that might serve as leads for the development of novel drugs. In this study, an ethanolic extract of leaves from Dillenia indica L. which belongs to family “Dilleniaceae”, was tested for in vitro antioxidant activity. Free radical scavenging assays, such as hydroxyl radical, hydrogen peroxide, 2, 2-diphenyl-1-picryl hydrazyl (DPPH), and reducing power assay were studied. The extract effectively scavenged hydroxyl, hydrogen peroxide radicals. It also scavenged DPPH radicals. Furthermore, it was found to have reducing power. All concentrations of leaf extract exhibited free radical scavenging and antioxidant power, and the preventive effects were in a dose-dependent manner. The results obtained in the present study indicate that the ethanolic extract of Dillenia indica L. could be considered a potential source of natural antioxidant.
Parshuram Shendge*, Leena Patil and Vilasrao Kadam
Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, Sector-8, C.B.D. Belapur, Navi Mumbai- 400 614, Maharashtra, India
14 April, 2011
19 May, 2011
26 June, 2011
01 July, 2011