IN-VITRO EVALUATION OF ANTIULCER ACTIVITY OF AQUEOUS EXTRACT OF MALVASTRUM TRICUSPIDATUMAbstract
There are several factors that may induce ulcers in human beings such as stress, chronic use of anti-inflammatory drugs, etc. Though in most cases, the etiology of ulcer is unknown, it has generally accepted that it is the result of an imbalance between aggressive factors and maintenance of the mucosal integrity through the endogenous defense mechanism. Thus, the search for a safe anti-ulcer drug that optimizes these properties is continuing, and part of the search is the evaluation of medicinal plants for gastroprotective properties. The Malvastrum tricuspidatum has used in folk medicine for the treatment of inflammation and gastrointestinal diseases. In this study, we assessed for anti-ulcer activities with aqueous extract and in-vitro method as the acid-neutralizing capacity and H+/K+ – ATPase inhibition activity method and. In acid-neutralizing capacity (ANC), the extract significantly reduced ANC to 9.33 at a concentration of 1500 mg as compared to 15.7 with standard Aluminium hydroxide + Magnesium hydroxide (500mg). While in H+ /K+ – ATPase inhibition activity, the extract showed maximum percentage inhibition of 62.18% at the concentration 100µg as compared to 69.56% with standard Omeprazole.