IN-VITRO EVALUATION OF TWO MARKETED BRANDS OF PARACETAMOL TABLETS USING QUALITY CONTROL TESTSAbstract
Paracetamol is a widely used non-prescription analgesic and antipyretic medicine. The study was conducted to assess the comparative in-vitro quality control parameters through the evaluation of weight variation, hardness, friability, disintegration time and dissolution profile between the commercially available tablet brands of paracetamol. Tablets of two manufacturers of the formulation were evaluated in two groups A and B. The similarities were found between both the groups. Both tablet brands of paracetamol (1.0 to 1.6%) showed acceptable weight variation and friability (below 1%). Both tablet brands were somewhat different in their hardness, disintegration time and dissolution profile. It can be concluded that standard quality control parameters always should be maintained not for paracetamol but also for all kinds of medicine for getting better drug products.
Satinder Kumar*, Shashikant and Ruchika Agnihotri
Global College of Pharmacy, Kahnpur Khui, Tehsil Anandpur Sahib, Distt.- Ropar, Punjab, India
19 May, 2012
25 June, 2012
27 August, 2012
01 September, 2012