IN-VITRO SENSITIVITY OF AMPHOTERICIN B, ITRACONAZOLE AND FLUCONAZOLE – RESISTANT AGAINST CANDIDA ALBICANSAbstract
Aim: To study In-Vitro sensitivity of Amphotericin B, Itraconazole and Fluconazole -Resistant against Candida albicans.
Methods and Results: A panel of 14 clinical isolates of Candida albicans was tested. Strains were labeled and given a unique identification number. Candida albicans ITCC 4718 were included as quality control organisms in each set of experiments. Interactions in vitro between Amphotericin B, Itraconazole, Voriconazole, and Fluconazole against Itraconazole-resistant Candida albicans clinical strains were determined. Fluconazole and Voriconazole exhibited the most potent interactions with synergy against at least 50% of isolates, and the average fractional concentration index was 0.38
Conclusion: Fluconazole and Voriconazole exhibited the most potent interactions with synergy against isolates and Antagonism was not found for any combination.
Significance and Impact of the Study: Fungal infections are frequently tricky to manage prudence has to be exercised in the use of antifungal drugs to capture any additional increase in the resistance.
Desh Deepak Singh* and Vinod Singh
Ph. D, Associate Professor and Head, Department of Microbiology, Barkatullah University, Bhopal- 462026, Madhya Pradesh, India
03 July, 2011
17 September, 2011
29 October, 2011
01 November, 2011