IN-VIVO AND IN-VITRO ANTIASTHMATIC STUDIES OF PLANT MICHELIA CHAMPACA LINN.Abstract
Michelia champaca known as champaca is belonging to family of Magnoliaceae. The present work consist of extraction and evaluation of anti-asthmatic activity of flowers of Michelia champaca Linn. Flowers was evaluated for anti-histaminic activity using isolated goat tracheal chain preparation and histamine induced Broncho-constriction in Albino mice. Michelia champaca Linn. expressively inhibited dose reliant contraction of goat tracheal chain produced by histamine and also exhibited significant protection by prolonging preconvulsion dyspnea time (PCD) in mice. Thus, Michelia champaca Linn. showed anti-allergic activity against histamine and hence possesses potential role in the treatment of asthma.
S. R. Shejale * and V. C. Yeligar
Department of Pharmaceutical Chemistry, Ashokrao Mane College of Pharmacy, Peth – Vadgaon, Maharashtra, India.
18 October 2019
04 February 2020
04 March 2020
01 October 2020