IN-VIVO ANTI-ARTHRITIC EFFECT OF COMPARATIVE STUDY OF POLYHERBAL FORMULATIONS (MUNIPAYN, RUMALAYA FORTE) IN FCA INDUCED ARTHRITIC RATS
AbstractRheumatoid arthritis (RA) is one of the most prevalent chronic inflammatory joint diseases which affect approximately 1% adult population in the worldwide. Polyherbal ayurvedic formulations (Munipayn and Rumalaya forte) reported to be effective as anti-inflammatory and anti arthritic activity. In-vitro anti-inflammatory of individual formulations (Munipayn and Rumalaya forte) were evaluated by albumin denaturation and Red blood cell membrane stabilization assay methods. In-vivo anti-arthritic activity of Munipayn (25 mg/kg and Rumalaya forte 40 mg/kg, bw, po) were evaluated against Frund’s complete adjuvant induced arthritis in rats. After the injection of FCA, the polyherbal formulations, standard was administered for 28 days. Both the formulations and standard showed a significant (P<0.001) reduction in paw volume, paw thickness, increase in WBC when compared to FCA treated rats. Histological reports also suggested that histological changes reversed in both formulations treated rats. Present study resulted that Munipayn and Rumalaya forte has significant anti-inflammatory, anti-arthritic activity against FCA-induced arthritis rats.
Article Information
19
2346-2352
863 KB
121
English
IJPSR
A. Bhargav, S. Shrikanta, Rama R. Nargund *, Sachindra L. Nargund H. J. Nisarga and H. Keshava
Department of Pharmacology, Nargund College of Pharmacy, Bangalore, Karnataka, India.
rnargund05@gmail.com
23 February 2024
26 March 2024
24 April 2024
10.13040/IJPSR.0975-8232.15(8).2346-52
01 August 2024
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