IN-VIVO ANTI-ARTHRITIC EFFECT OF ETHANOL EXTRACT OF SESBANIA GRANDIFLORA SEEDS ON COMPLETE FREUND’S ADJUVANT (CFA)-INDUCED ARTHRITIS IN RATSAbstract
Herbal medicines are in substantial demand in the developed country for primary healthcare because of their high efficacy, safety, and few side effects. Sesbania grandiflora is an ancient plant that belongs to the family Fabaceae. Traditionally, it is used for the treatment of various disorders such as diabetes, anxiety, hepatotoxicity, ulcer, and anti-inflammatory activity. Therefore the present investigation was undertaken to investigate the anti-arthritic potential of Sesbania grandiflora seeds extract against CFA-induced arthritis in experimental animals. The Ethanol extract of Sesbania grandiflora seeds was prepared by liquid-liquid extraction procedure, and phytochemical analysis of extract was done by the different chemical test as well as HPLC. Daily oral treatment of ethanol extract of Sesbania grandiflora and UK-356618 for twenty one days. After nine day of CFA administration improve the body weight and attenuated the paw volume, hepatic biomarkers as well as hematological parameters such as hemoglobin, RBC, Hb, WBC, and ESR of experimental animals. Finding of the current investigation demonstrated that the ethanol extract of Sesbania grandiflora along with UK-356618 possesses potent anti-arthritic activity; further investigations are required to explore the mechanism responsible for its anti-arthritic activity.
S. N. Pandey and B. C. Semwal *
Department of Pharmacology, Institute of Pharmaceutical Research GLA University, Mathura, Uttar Pradesh, India.
03 April 2020
09 August 2020
05 November 2020
01 April 2021