IN-VIVO ANTICONVULSANT ACTIVITY OF 2-SEMICARBAZONO-1-HYDROXY, 1-[2-CHLOROPHENYL] -2-[4′-METHOXYPHENYL] ETHANEAbstract
A benzoin derivative of 2-Semicarbazono-1-hydroxy, 1-[2-chlorophenyl]-2-[4′-methoxyphenyl] ethane (2C4MBS) was synthesized by benzoin condensation followed by addition reaction. The structure elucidation done using single XRD studies. Maximal electroshock seizure (MES) model was used in the present study to evaluate the anticonvulsant activity of the test drugs. MES seizures were induced by an electro convulsiometer by delivering electroshock of 60 mA current transauricularly for 0.2 sec in mice using corneal electrodes. The incidence and duration of the extensor tonus were noted. Phenotyin is used as standard, synthesized drugs of 5 and 10 mg/Kg were subjected in test animals. The duration of the tonic hind leg extension phase of MES convulsions expressed as the arithmetic mean ± SE and was analyzed by one-way analysis of variance (ANOVA) followed by Dunnet′s ′t′ test. Data were analyzed using one-way analysis of variance (ANOVA), and group means were compared using the Multiple Comparison test using Instat-V3 software. P values < 0.05 were considered significant. Hematological and blood biochemical analyses also performed, and the results revealed that the synthesized drug found to be therapeutic potential.
B. Thanuja * and C. Kanagam
Department of Chemistry, Sri Sairam Engineering College, Tambaram, Chennai, Tamil Nadu, India.
06 December 2019
02 March 2020
06 March 2020
01 December 2020