IN-VIVO APPRAISAL OF PHARMACOLOGICAL ACTIVITY OF BACOPA MONNIERI AND ITS HPLC ANALYSIS FOR BACOSIDE AAbstract
Bacopa monnieri is a herb, known to possesses various pharmacological and medicinal properties. Aim: The objective of the study was to analyse the activity of Bacopa monnieri as an antipyretic, analgesic and anti-ulcerogenic agent. Methods: Indomethacin was used as the standard of comparison for this study. Animals were arbitrarily separated into three groups of six animals in each group. The first group was accorded saline, while the second group was administrated with the test drug Bacopa monnieri, and the third group received indomethacin. Hot plate test and acetic acid test were performed to analyze the analgesic activity of Bacopa monnieri. The antipyretic activity was evaluated by a yeast solution which was used to induce fever before administering the drugs. For the ulcerogenic activity, the rats were kept on a fast to induce ulcers and then the action of Bacopa monnieri was evaluated. HPLC analysis of the Bacopa monnieri sample was performed to evaluate the active components. Conclusion: It was possible to conclude that Bacopa monnieri showed significant analgesic, antipyretic and anti-ulcerogenic effects in experimental rats.
S. E. Prince *, A. P. Das and G. Arumugam
Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India.
20 August 2018
31 October 2018
09 November 2018
01 May 2019