INCREASED ENZYMATIC ACTIVITY OF THYROID PEROXIDASE-TREATMENT FOR CONGENITAL HYPOTHYROIDISMAbstract
Congenital Hypothyroidism may be defined as a heterogeneous group of disorders characterized by goiter or cretinism due to an absolute or relative deficit of the enzyme Thyroid Peroxidase (TPO), and it is action. Chronic hypothyroidism also leads to goiter and cretinism associated with end gland damage, dysfunction, cancer, and failure, including the retina, kidney, nervous system, heart, and vascular tissue damage. The screening for Congenital Hypothyroidism (CH) may either be in the form of a thyroid function test or via thyroid peroxidase antibodies test, as recently recommended by the Thyroid Federation Association (TFA). Unto now, the treatment of goiter and cretinism is levothyroxine supplement and gland surgery removal. This review will establish the effectiveness of the enzymatic drug (TPO) and its indication for the treatment of PCH when compared to other therapies. This review also highlights the enzyme thyroid peroxidase (TPO) role and current treatment strategies on Congenital Hypothyroidism (CH).
P. J. Sujitha and S. Arunkumar *
Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam, Tamil Nadu, India.
08 June 2020
09 October 2020
03 May 2021
01 June 2021