INDUCED COAGULATION AS A COMPLICATION OF INFLAMMATORY REACTIONS IN MICE TREATED WITH MONOSODIUM GLUTAMATEAbstract
Monosodium glutamate (MSG) is a familiar food additive processed to enhance the taste. This work was carried out to investigate the effect of MSG on platelets profile and indices of thrombus formation together with the detection of some plasma inflammatory markers. The study used adult male mice divided into five groups: a control group and four groups treated with different doses of MSG (2, 4, 8 and 16 mg/kg, respectively for 30 days, orally). The mice treated with 8 and 16 mg/kg of MSG resulted in significant high levels of plasma inflammatory markers such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP). Also, thrombocytosis, significant increase in fibrinogen (FIG) concentration, low values of prothrombin time (PT) and the associated international normalized ratio (INR) compared to the control group. Our study suggests that MSG initiates inflammatory reactions, which may induce thrombocytosis and coagulation complication in mice model.
G. M. Badr * and A. I. Algefare
Department of Biological Sciences, Faculty of Science, King Faisal University, Kingdom of Saudi Arabia.
02 July 2018
20 September 2018
22 September 2018
01 March 2019