INFLUENCE OF ALLICIN ON PHARMACOKINETICS AND PHARMACODYNAMICS OF PIOGLITAZONE: AN HERB-DRUG INTERACTION STUDY IN RATSAbstract
Many herbs/phytochemicals are proved to have anti-diabetic properties and patients in the treatment of diabetes increased their usage. Administration of herbs and allopathic drugs has a chance of interaction between them, leading to alterations in pharmacokinetics and pharmacodynamics of the drug. The present study was aimed to know the influence of phytoconstituent (Allicin) on the pharmacokinetic and pharmacodynamic parameters of the drug. Pioglitazone is a thiazolidinedione class of oral anti-diabetic drug which was metabolized by CYP enzymes. The combination of piglitazone with allicin, increases the AUC in normal and diabetic rats. The pharmacodynamic parameter like blood glucose levels of diabetic rats was decreased due to the increase in the bioavailability of the drug. Allicin shows inhibitory action on CYP enzymes and decreases the metabolism of pioglitazone. However, the combination of pioglitazone with allicin alters the metabolism of the drug in diabetic rats and doses of herb-drug were monitored cautiously.
Pavani Uppu and Narsimha Reddy Yellu *
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India.
19 November 2020
20 August 2021
23 August 2021
01 October 2021