INFLUENCE OF FLUCONAZOLE PRE-TREATMENT ON ANTIDIABETIC ACTIVITY OF THIAZOLIDINEDIONES IN DIABETIC RATSAbstract
The influence of fluconazole pre-treatment on the hypoglycaemic effect of pioglitazone (10 mg/kg, p.o) and rosiglitazone (720µg/kg, p.o) was studied. This study was conducted on diabetic rats of either sex, randomly distributed into two different groups. Diabetes was induced by administering 120mg/kg of alloxan intraperitonially. Then they were pretreated with fluconazole (36 mg/kg) in 2% w/v gum acacia suspension for seven days. On eighth day, rosiglitazone and pioglitazone were administered to respective groups one hour after fluconazole treatment. Blood samples were collected by retro orbital plexus under light ether anesthesia at different time intervals up to 24 hours. The hypoglycaemic activity of thiazolidinediones was studied and it indicated that fluconazole pretreatment has enhanced the hypoglycaemic effect of pioglitazone and rosiglitazone, at higher dose, significantly. Hence it is suggested that during the concomitant usage of fluconazole and thiazolidinediones, the therapeutic drug monitoring is essential and may also require readjusting the dose and frequency of administration of thiazolidinediones.
A. K. Patel *, J. Kaur, D. K. Yadav, M. Hasan and P. K. Tyagi
College of Pharmacy, Shree Ganpati Institute of Technology, Hapur, UP, India
26 May, 2016
21 July, 2016
27 July, 2016
01 November, 2016