INFLUENCE OF THE SUPERDISINTEGRANTS IN NIFEDIPINE RELEASE FROM OSMOTIC PUSH-PULL TABLETSAbstract
Push-pull osmotic pumps are controlled drug delivery systems for drugs with a broad range of solubilities; especially drugs that are poorly water-soluble. The aim of the present study was to evaluate the performance of the superdisintegrants (SD), crospovidone (CPVP), croscarmellose sodium (CS), and sodium starch glycolate (SSG), in push-pull tablets containing Nifedipine (NP) as a model drug. We performed an in-vitro dissolution test with phosphate buffer (0.05M) at pH 7.5 for 12 h. The amount of released NP was determined using a UV/Visible spectro-photometric method at a wavelength of 238 nm. At 12 h of release, the profile of CPVP- and CS-containing osmotic tablets was like that of the reference product Adalat OROS®, whereas the SSG-containing tablet showed differences. It is very important mention that in the first 6 h of the assay, all release profiles were different compared to the commercially available reference product. The tablets containing superdisintegrants showed faster drug delivery rates and a reduction in lag time.
J. E. Hernández Torres, E. Hernández Baltazar, M. J. B. Bernad and L. M. M. Contreras *
Universidad Autónoma Metropolitana, Unidad Xochimilco, Departamento de Sistemas Biológicos, Calzada del Hueso 1100 Col, Villa Quietud Delegación Coyoacán C.P, México D.F., México.
18 August 2018
08 November 2018
17 November 2018
01 May 2019