INHIBITION OF SPERMATOGENESIS WITH THE TREATMENT OF 50% METHANOLIC EXTRACT OF MAYTENUS EMARGINATA LEAVES IN ALBINO RATS
AbstractThe plant Maytenus emarginata belongs to the Family Celastraceae also known as Kankhera in Hindi have used effectively for the treatment of wide range of disorder as digestive ailments, nerve afflictions, Heart ailments, inflammation, nervous system, Rashes and as a tonic and anti stress. The present investigation is planned to evaluate safety and reversible contraceptive efficacy of aqueous methanolic extracts of Maytenus emarginata leaves to develop a orally effective and reversible male contraceptive. Animal were orally administrated with extract of Maytenus emarginata leaf at the dose of 50,100,200 mg/kg/ body wt/day per oral dose for 60 days. A marked dose dependent decrease in the count and motility of the sperms of treated rats was observed compared with control. Furthermore, pregnancy rate in females markedly reduced by 80% after the mating with male treated with 50,100,200 mg/kg Maytenus emarginata leaf extract. At the same time significant decrease were detected in seminal vesicles and testicular weight of rats that received
Article Information
25
3379-87
458
1244
English
IJPSR
Deepak Kumar Sharma and Pratap Chand Mali*
Reproductive Biomedicine and Natural Products Lab, Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, India
malipc_zool@yahoo.co.in
30 March, 2016
12 July, 2016
14 July, 2016
10.13040/IJPSR.0975-8232.7(8).3379-87
01 August 2016
Download