INSIGHTS INTO VARIOUS NOVEL SYNTHETIC STRTAEGIES FOR FLAVONE DEVELOPMENT: PHARMACOLOGICAL IMPORTANCEAbstract
Flavones make up one of the biggest subgroups of the secondary metabolite class of flavonoids, which has more than 9000 known structural variations. It is shown that they are present in practically all plant tissues naturally. In the literature, many flavone aglyca and their O- or C-glycosides have been described. Numerous potential uses exist for flavones due to their wide range of biological activities in plants and their numerous interactions with other species. These include plant breeding, ecology, agriculture, human nutrition, and pharmacology, in addition to plant breeding. Flavones are abundant polyphenols of plant origin that have been extensively studied for their pharmacological properties. Flavones are a subclass of flavonoids with their structural basis in 2-phenylchromen-4-one (flavus = yellow). Cereals and plants are the primary sources of flavones. Since flavones are physiologically active substances, several synthetic techniques have been developed. We have attempted to include a variety of synthetic methods for the synthesis of flavones in this update. Claisen-Schmidt condensation and Baker-Venkatraman synthesis are two well-known techniques for creating flavones. It is widely known that derivatives of flavones exhibit a wide range of pharmacological actions. This study paves the way for thorough biochemical and molecular characterizations as well as the creation of direct metabolic engineering techniques for modifying flavone production in plants to increase their nutritional and/or medicinal value.
Anil G. Dhawade *, Satish Kumar Sarankar and Pooja A. Chacherkar
Shree Sadguru Datta Institute of Pharmacy, Kuhi, Dist. Nagpur, Maharashtra, India.
27 December 2022
27 March 2023
30 May 2023
01 September 2023