INVESTIGATION ON IN VITRO CYTOTOXIC ACTIVITY OF A SELECTED WILD CUCURBITACEAE PLANT CORALLOCARPUS EPIGEAUS AGAINST CANCERAbstract
Medicinal plants have been investigated for possible anti-cancer effects. Corallocarpus epigaeus (Roth & willd.) cl. is an ethnobotanically important wild climber that belongs to the family Cucurbitaceae. The aim of the present study is to examine the cytotoxic activity of Corallocarpus epigaeus (Roth & willd.) cl., on two tumor cell lines. The methanolic root extract of the plant Corallocarpus epigaeus (Roth & willd.) cl. was subjected to cytotoxic activity study against two human cancer cell lines (MCF7, human breast adenocarcinoma and HT-29, human colon carcinoma) using the MTT assay. The concentration of methanolic root extract yields the IC50 value of 183.33±0.7 µg/ml and <62.5µg/ml respectively for HT-29 and MCF-7 cell lines by MTT assay. The results showed that the root extract of Corallocarpus epigaeus has potential anti-cancer activity against MCF-7 and HT-29 human cancer cell lines.