ISOLATION AND EVALUATION OF CASSIA AUNGOSTIFOLIA SEED MUCILAGE AS GRANULATING AGENTAbstract
Cassia aungostifolia is a common herbaceous belongs to the family of Caesalpiniaceae. Seeds of plant contain gluco-mannose hence attempt to evaluate the seeds for suitability as tablet binder is considered and the present exploration repots the isolation of mucilage of Cassia aungostifolia seed. The DSC and FTIR thermograms of drug and mucilage indicated no chemical interaction. Phytochemical and Physiochemical characteristics of mucilage were studied which confirmed the mucilage nature. The mucilage was evaluated for its granulating and binding properties in compressed tablet using Diltiazem HCl as model drug. The granules prepared by mucilage were compared with xanthan gum, which was used as standard binder. The tablets had good physiochemical properties and the drug release was more than 95% within 2hr. It was observed that increasing the concentration of mucilage increases hardness and decreases the disintegration time. All the formulations were subjected to stability studies for three months as per ICH guidelines all four formulation showed stability with respect to release pattern and other parameters which confirm the use of mucilage as excipient.
Sudarshan Singh* and SangeetaSingh
Shree HNS Institute of Pharmaceutical Education and Research, Rajkot, (Gujarat), India
15 April, 2010
16 June, 2010
01 August, 2010
15 August, 2010