ISOLATION OF CONTINENTALIC ACID FROM ARALIA CACHEMIRICA AND ITS IMMUNO-BIOLOGICAL EVALUATIONAbstract
In continuing search for compounds with immunomodulatory activity, plant Aralia cachemirica has been found to contain continentalic acid (CA). Isolation of this pharmacologically significant diterpinic acid from Aralia cachemirica is novel. Chemical structure of this compound was identified by spectral analysis as (-)-pimara-8(14), 15-dien-19-oic acid, which has been isolated from A. cordata and A. continentalis. This compound has been evaluated for its effect on immunomodulaion. CA was found to inhibit production of pro-inflammatory cytokines (IL-6, TNF-α) & nitric oxide (NO) in LPS induced macrophage activation, suppressed antibody titres & delayed type hypersensitivity reaction (DTH) when orally administered and increased the phagocytic activity by clearance of Candida albican infection from peritoneal cavity in mouse model system.
Ekta Sharma , Bhupinder Singh Arora , Anamika Khajuria , Tabasum Sidiq , Dharma Kishore * and Ram A. Vishwakarma
Professor, Department of Chemistry, Banasthali University, P.O. Banasthali Vidyapith, Tonk-304022, Rajasthan, India
04 May, 2011
14 June, 2011
13 July, 2011
01 August, 2011