ISOLATION OF PRELIMINARY PHYTOCONSTITUENTS AND ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF CALOTROPIS GIGANTEA LINN. LEAVES EXTRACTSAbstract
The present studies that Isolation of preliminary phytoconstituents and anti-inflammatory and antipyretic activity of Calotropis gigantea Linn. Leaves Extracts. Therapeutic use of plants for the treatment of human illnesses dates back over man millennia. Evidence of their effectiveness in the diagnosis, cure and prevention of disease states exists in every culture throughout the world. Today “traditional medicine,” characterized by the use of herbs and other natural products still remains a regular component of health care in countries such as China, Japan, India, South America and Egypt. The search for anti-inflammatory and analgesic agent in modern was marked by the introduction of salicin for the treatment of inflammatory swellings due to rheumatic fever and rheumatoid arthritis. The ethanol extract and distilled water extract showed good significant reduction in paw oedema as compared to control group, where as Petroleum ether (60-80oC) extract, Chloroform extract, Ethyl acetate, n-Butanol has showed comparatively less significant reduction in paw oedema volume. The chloroform and n-butanol extract showed good significant reduction in rectal temperature as compare to control group, where as pet. ether, ethyl acetate, ethanol and distilled water extracts showed less significant reduction in rectal temperature. Hence, to put into the active principle of Calotropis gigantea linn like glycoside, sterols, carbohydrate, flavonoids, terpenoide may be responsible for anti-inflammatory and antipyretic activity.
Mohammed Rageeb Mohammed Usman*, Md. Abullais Md. Usman and Sudip A. Patil
Department of Pharmacognosy, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India
18 December, 2011
21 February, 2012
29 March, 2012
01 April, 2012