LABRAFAC WL1349 AIDED LYOPHILIZE SOLID DISPERSION OF OLMESARTAN MEDOXOMILAbstract
Water solubility is the rate limiting step in dissolution and bioavailability. Olmesartan medoxomil is BCS class-II drugs having low water solubility. Olmesartan medoxomil acts on cardiovascular system and used in the treatment of hypertension as antihypertensive agent. Olmesartan medoxomil have low water solubility and low bioavailability as 26%. In this research study we made Olmesartan medoxomil solid dispersion for increasing water solubility of Olmesartan medoxomil. HPMC and PVP were used as hydrophilic polymer while Lyophilization technique was used as a method of preparation of solid dispersion. We evaluated the effects of freeze drying in process yield, solubility and total Olmesartan content of the solid dispersion. This solubility study shows significant increase in solubility of solid dispersion of Olmesartan medoxomil than pure Olmesartan medoxomil. Dissolution study illustrate that, there was improved dissolution rate when compared to plain Olmesartan. The result and conclusion of this research suggest that the solid dispersion prepared in this research has successfully improved the solubility of Olmesartan medoxomil.
Rakesh Madhukar Bachhav, Avinash Balasaheb Gangurde, Rupesh Krishna Deore, Vinod A. Bairagi and Rahul Yuvraj Pagar *
Department of Pharmaceutics, K. B. H. S. S. Trust’s Institute of Pharmacy, Oppo. Jajuwadi Compound, Bhaygaon Raod, Malegaon, Nashik, Maharashtra, India.
15 March 2023
04 June 2023
06 June 2023
01 November 2023