LEISHMANICIDAL EFFECTS OF OLEA EUROPAEA LINN. EXTRACT AGAINST PROMASTIGOTE AND AMASTIGOTE FORMS OF SOME LEISHMANIA SPPAbstract
Here, we evaluated the in vitro antileishmanial activities of Olea europaea linn. leave extract (OLE) on some Leishmania spp. OLE (0–160 𝜇g/mL) was considered against promastigote and intracellular amastigote forms of L. tropica (MHOM/IR/2002/Mash2) and L. major (MRHO/IR/75/ER) using MTT assay and in a macrophage model, respectively. The obtained findings demonstrated that OLE significantly (𝑃<0.05) inhibited the growth rate of promastigote and amastigotes as a dose and time dependent response. To conclude, the current investigation exhibited effective antileishmanial activity of OLE.
F. Kheirandish, B. Delfan, S. Fallahi, M. H. Kayedi, M. Rashidipour and S. Jahanbakhsh*
Bam University of Medical Sciences, Bam, Iran.
15 March, 2017
24 May, 2017
17 September, 2017
01 November, 2017