LIPID NANOCARRIERS FOR NOSE TO BRAIN DELIVERY: RECENT UPDATESAbstract
In recent years, the nasal route is gaining increasing importance for systemic administration of drugs and targeting to brain. The drug delivery to the brain is limited due to several factors, including presence of blood-brain barrier, enzymatic degradation, and efflux of drug by P-glycoprotein. Nasal route is employed to target the brain using various direct pathways via nasal mucosa and to bypass blood-brain barrier. The nasal route has limitations like small surface area, possibility of nasal irritation, and low volumes of administration. Various strategies have been employed in order to enhance nasal absorption and drug uptake in the brain. Nanotechnology-based formulations is one of the most investigated approaches in recent years for effective brain targeting. Lipid-based nanocarriers serve as a promising strategy owing to their ability to facilitate drug permeation through the nasal mucosa and reduce drug efflux by the blood-brain barrier by inhibiting efflux transporters. This review summarizes nose to brain drug transport pathways, mechanism of nasal absorption, various strategies used to improve nasal absorption, and a detailed account on lipid-based carriers employed for a nose to brain delivery.
S. S. Deshkar *, M. S. Jadhav, S. A. Todmal and S. V. Shirolkar
Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.
04 August 2020
09 July 2021
12 July 2021
01 October 2021