LIPID POLYMER-BASED BIO-INSPIRED DRUG DELIVERY SYSTEMAbstract
Gene targeting has been a promising drug delivery system, thereby helping to improve the impaired functioning in various disorders. “Lipoplexes” and “Polyplexes” incorporates lipids and polymers combined with bioactive molecules, drugs, or genes are one of the newly developing systems. The need to protect genes from degradation, allowing them to reach their target site and to promote an efficient endosomal escape, to achieve this, the delivery system has been developed. Formulation studies and clinical trials are carried out on these systems, and they are found to be very useful in the treatment of various disorders such as Cancer, Parkinsonism, Cystic Fibrosis, Rheumatoid Arthritis, Antisense Therapy, and others. The major advantage of these systems over existing liposomal delivery is that they have gene silencing activity and are highly non-immunogenic & non-viral techniques of delivering genes to the target site. Encapsulating the drug within the lipids or the polymers and targeting them at the specific site reduces the non-specific reactions. The current review article focuses on the formation, mechanism of action, large-scale preparation, characterization, and applications of these lipoplexes and polyplexes that makes this system superior to other non-viral nanoparticulate drug delivery system.
Riddhi Ahuja and Meenal. M. Rane *
SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Gate No. 1, Mithibai College Campus, V.M. Road, Navpada, Suvarna Nagar, Vile Parle (West), Mumbai , Maharashtra, India.
09 December 2020
12 May 2021
29 May 2021
01 January 2022