LIPID PROFILE VARIABLES AND PREDICTION OF THE SEVERITY OF CORONARY ARTERY DISEASE IN TUNISIAN TYPE 2 DIABETIC PATIENTSAbstract
DM is characterized by insulin resistance and dyslipidemia, in particular, high levels of total cholesterol, triglycerides and LDL, and low levels of HDL-C, wich confer increased risk for CAD. Our study aimed to evaluate lipid profile in type 2 diabetic (T2DM) patients with coronary artery disease (CAD) in Tunisian population. Plasma levels of lipid profile variables were determined in 148 CAD patients with T2DM and in 159 patients with only CAD. Severity of CAD was quantified according to the prevalence of multivessel disease and the degree of coronary stenosis. Our results didn’t show any significant differences between diabetic and non diabetic patients in lipid profile variables. We didn’t found significant differences between the number of vessel disease and the extent of coronary stenosis, and lipid variables levels potentially reflecting the absence of a relationship between lipid profile and the severity of CAD. Using the receiver operating characteristic (ROC) curve that included all these variables, TG was found to be the single most powerful predictor of the severity of coronary artery disease in T2DM.
N. Bouzidi *, S. Sahli, L. Khlifi, H. Graiet, F. Maatouk, H. Gamra and S. Ferchichi
Biochemistry Laboratory, Faculty of Pharmacy, University of Monastir, Tunisia.
25 August, 2016
05 October, 2016
05 November, 2016
01 March, 2017