LIQUISOLID TECHNIQUE: A REVIEW

Dissolution of drug and its release from the dosage form have basic impact on bioavailability. Bioavailability depends on solubility of drug. Solubility is major challenge for the pharmaceutical industry with the developments of new pharmaceutical products. There are several approaches for solubility enhancement which includes micronization, Nanonisation, use of salt forms, use of surfactant, solid dispersion, and supercritical fluid recrystalization etc. Liquisolid technique is novel and efficient approach for solubility enhancement. According to this method the conversion of water insoluble drug into dry looking, non adherent, free flowing and acceptably compressible powder by incorporating into suitable non volatile solvents, carrier material and coating materials. This free flowing powder is than subjected to Preformulation studies like Fourier transformed infrared spectroscopy, differential scanning Calorimetry for compatibility studies , angle of slide, flow properties, solubility studies, calculation of liquid load retention potential, liquid load factor etc. These free flowing powders are subjected to compression for tablet or filled in capsules. The mechanism for solubility enhancement includes increase in wettability and surface of drug available for dissolution. This method is efficient, economic, viable for industrial production, also useful in control drug delivery system. Hence due to above reasons liquisolid technique is most efficient and novel approach for solubility enhancement.