LYMPHATIC TARGETING SYSTEM USING NANO-FORMULATION: CHALLENGES AND APPROACHESAbstract
The lymphatic system is the subpart of the systemic circulation for maintaining immune function; this system is mainly known as a drainage system to removes foreign bodies. This system consists of various lymphoid organs and tissues. The lymphatic system based on physiological function as absorption and micro-particulate uptake by these routes the bioavailability and efficacy were enhanced and undergone hepatic first-pass metabolism. The Lymphatic system is mainly used for the targeted delivery of chemotherapeutic agents; they also are modified for partial uptake into the lymphatic system to improve efficacy with the reduced systemic distribution. The anatomy and physiology of the lymphatic system, route of administration, physiochemical properties of drug carriers, and model for lymphatic uptake are also assessed; the novel system reviewed are SLN (solid lipid nanoparticle), liposomes, self-emulsifying system, polymeric micelles, dendrimers, carbon nanotube, hybrid nano-system, mesoporous silica nanoparticle. Lymphatic delivery employed various nanocarriers with the latest technology for various diseases to get a better therapeutic outcome.
J. Desai * and T. Patel
Ramanbhai Patel College of Pharmacy, Charusat University, Charusat Campus, Anand, Gujarat, India.
01 April 2020
01 August 2020
16 August 2020
01 April 2021