LYOPHILIZATION- A PROCESS OF OPTIMIZATION OF DOSAGE FORMSAbstract
Freeze-drying is a method of removing water by sublimation of ice crystals from frozen material. Suitable parameters of process application allow us to obtain the best quality products compared to products dried with traditional methods. In the pharmaceutical field, lyophilization has become an important subject to ongoing development and its expansion. In this 21st century, Lyophilization emerges to be a novel trend for the drying of pharmaceuticals and biological those is thermolabile or are unstable in aqueous form but stable for longer periods in their dried form. This article provides an overview on the process of lyophilization, how the freeze-drying cycle is designed, discussing several important parameters which are important for an understanding of this process as well as their role in the designing of an optimized freeze-drying cycle, so that a robust and economical process of lyophilization can be developed which does not impact the product quality. This review focused on the recent advances and its targets in the near future.
A. Pande *, P. Dhekale and V. Thorat
Department of Pharmaceutics, PDEA’s Shankarrao Ursal College of Pharmaceutical Sciences and Research Centre, Pune, Maharashtra, India.
06 January 2020
27 March 2020
30 March 2020
01 October 2020