MANGIFERIN LOADED NANOPARTICLES FOR CANCER THERAPY: AN APPROACH FOR IMPROVEMENT OF BIO-EFFICACY USING NANOTECHNOLOGYAbstract
Cancer is the malignant form of uncontrolled growth of cells and tissues. The drugs currently used for treating cancer can only increase the lifespan of a patient but cannot cure the disease due to their high toxicity and poor targeting of specific sites. Drugs developed from natural compounds are believed to combat those problems due to their ability to stimulate various physiological pathways with multiple targets. However, the use of natural compounds is restricted because of their physicochemical characteristics. This research article focuses on the use of Mangiferin as anti-cancer agent and its safe and effective delivery using nanotechnology. Mangiferin-loaded poly (lactic-co-glycolic acid) nanoparticles were prepared by single emulsion-solvent evaporation technique and evaluated for yield, particle size, morphology analysis, zeta-potential, drug loading, encapsulation efficiency, in-vitro drug release study and MTT assay on A549 cell line. Mangiferin was successfully loaded onto polymeric nanoparticles using a simple single emulsion solvent evaporation technique using PLGA as a polymer and PVA as a stabilizer with spherical narrow size distribution. Mangiferin-loaded PLGA NPs proved to be more cytotoxic to A549 cell lines than the free mangiferin solution with reduced IC50. Various studies in this article discussed the mangiferin-loaded polymeric nanoparticles and how the bio-efficacy has been improved for treating cancer.
Anima Debbarma *, Probin K. R. Roy, T. C. Lalhriatpuii and Hauzel Lalhlenmawia
Department of Pharmacy, Regional Institute of Paramedical & Nursing Sciences, Zemabawk, Aizawl, Mizoram, India.
10 August 2022
27 September 2022
23 October 2022
01 April 2023