MANNICHBASES: AN OVERVIEW OF HETEROCYCLIC COMPOUND WITH VARIOUS BIOLOGICAL ACTIVITIESAbstract
In Organic chemistry, largest families of organic compounds belong to heterocyclic compounds. In place of a carbon atom incorporation of an oxygen, a nitrogen, a sulfur, or an atom of a related element gives rise to a heterocyclic compound..Heterocyclic compounds are of very essential for our day-to-day life. It has a broad range of applications in medicinal chemistry as well as in agrochemicals products. A Mannich base is a beta-amino-ketone, which is formed in the reaction of an amine, formaldehyde and a carbon acid, and it is a carbon-carbon bond-forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. This literature study enlightens the fact, that Mannich bases of heterocyclic compounds are highly reactive and are recognized to possess potent diverse activities like, anti-inflammatory, anticancer, antibacterial, antifungal, anticonvulsant, anthelmintic, anti-tubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. In this review various biological activities of Mannich bases of heterocyclic compound derivatives reported is discussed.
C. Geethapriya * and Karthikeyan Elumalaiim
Department of Pharmaceutical Chemistry, R. R. College of Pharmacy, Chikkabanavara, R. R. Layout, Bangalore, Karnataka, India.
07 November 2020
18 May 2021
13 June 2021
01 December 2021